first_imgOne of the elderly residents on Dr McCloskey Crescent in Glenties who were locked into their homes.Irish Water has agreed NOT to install water meters outside the homes of residents in Glenties who oppose their installation.It follows a major stand-off between the company and locals in the town this week after the homes of elderly residents were blocked by Irish Water engineers.Now, following a meeting between the company and locals, Irish Water has agreed to approach individual residents. Irish Water has agreed not to install water meters in Glenties where individual residents do not want them.o approach individual homeowners on the issue.If a resident does not want a water meter, then Irish Water has agreed not to install one.Speaking following the agreement community representative Brian Carr said the move makes common sense.“After meeting with a representative of Irish Water on site here in Glenties this morning, a major breakthrough has been reached. Irish Water have agreed to contact any home who has a poster stating they do not want a watermeter installed. If that homeowner states they do not give permission, Irish Water will not install a meter for their premises.”“At all times this is what we wanted, it is unfortunate that this agreement could not have been made earlier this week as the turmoil and fear that have been created was totally unnecessary.” “Notice of works commencing was not given to the people of Glenties and on Monday morning Irish Water contractors moved into a small estate in Glenties. These houses are predominantly occupied by elderly residents, these residents were blocked in their homes and were feared.“The attitude of the Irish Water representives towards residents has created much of the ill feeling.“We are hoping that real lessons have been learned by Irish Water, all people are wanting is to be treated with respect and their human rights upheld.“The support and solidarity of the community have achieved this agreement. We will continue to support all our neighbours whether they want a metre installed or not.”He added that Right2Water Donegal will be meeting with representatives in the community over the weekend to inform people of their rights. IRISH WATER IN CLIMBDOWN WITH GLENTIES RESIDENTS OVER WATER METERS was last modified: May 1st, 2015 by StephenShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)last_img read more

Followup study confirms success of physiological test for autism

first_img Source: Jun 19 2018One year after researchers published their work on a physiological test for autism, a follow-up study confirms its exceptional success in assessing whether a child is on the autism spectrum. A physiological test that supports a clinician’s diagnostic process has the potential to lower the age at which children are diagnosed, leading to earlier treatment. Results of the study, which uses an algorithm to predict if a child has autism spectrum disorder (ASD) based on metabolites in a blood sample,”We looked at groups of children with ASD independent from our previous study and had similar success. We are able to predict with 88 percent accuracy whether children have autism,” said Juergen Hahn, lead author, systems biologist, professor, head of the Rensselaer Polytechnic Institute Department of Biomedical Engineering, and member of the Rensselaer Center for Biotechnology and Interdisciplinary Studies (CBIS). “This is extremely promising.”It is estimated that approximately 1.7 percent of all children are diagnosed with ASD, characterized as “a developmental disability caused by differences in the brain,” according to the Centers for Disease Control and Prevention. Earlier diagnosis is generally acknowledged to lead to better outcomes as children engage in early intervention services, and an ASD diagnosis is possible at 18-24 months of age. However, because diagnosis depends solely on clinical observations, most children are not diagnosed with ASD until after 4 years of age.Rather than search for a sole indicator of ASD, the approach Hahn developed uses big data techniques to search for patterns in metabolites relevant to two connected cellular pathways (a series of interactions between molecules that control cell function) with suspected links to ASD.”Juergen’s work in developing a physiological test for autism is an example of how the interdisciplinary life science-engineering interface at Rensselaer brings new perspectives and solutions to improve human health,” said Deepak Vashishth, CBIS director. “This is a great result from the larger emphasis on Alzheimer’s and neurodegenerative diseases at CBIS, where our work joins multiple approaches to develop better diagnostic tools and biomanufacture new therapeutics.”The initial success in 2017 analyzed data from a group of 149 people, about half of whom had been previously diagnosed with ASD. For each member of the group, Hahn obtained data on 24 metabolites related to the two cellular pathways–the methionine cycle and the transsulfuration pathway. Deliberately omitting data from one individual in the group, Hahn subjected the remaining dataset to advanced analysis techniques and used results to generate a predictive algorithm. The algorithm then made a prediction about the data from the omitted individual. Hahn cross-validated the results, swapping a different individual out of the group and repeating the process for all 149 participants. His method correctly identified 96.1 percent of all typically developing participants and 97.6 percent of the ASD cohort.Related StoriesAtypical eating behaviors may indicate autismScientists make breakthrough in understanding the genetics of common syndromic autismDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustThe results were impressive and created, said Hahn, a new goal: “Can we replicate this?”The new study applies Hahn’s approach to an independent dataset. To avoid the lengthy process of gathering new data through clinical trials, Hahn and his team searched for existing datasets that included the metabolites he had analyzed in the original study. The researchers identified appropriate data from three different studies that included a total of 154 children with autism conducted by researchers at the Arkansas Children’s Research Institute. The data included only 22 of the 24 metabolites he used to create the original predictive algorithm, however Hahn determined the available information would be sufficient for the test.The team used their approach to recreate the predictive algorithm, this time using data of the 22 metabolites from the original group of 149 children. The algorithm was then applied to the new group of 154 children for testing purposes. When the predictive algorithm was applied to each individual, it correctly predicted autism with 88 percent accuracy.Hahn said the difference between the original accuracy rate and that of the new study can likely be attributed to several factors, the most important being that two of the metabolites were unavailable in the second dataset. Each of the two metabolites had been strong indicators in the previous study.Overall, the second study validates the original results, and provides insights into several variants on the approach.”The most meaningful result is the high degree of accuracy we are able to obtain using this approach on data collected years apart from the original dataset,” said Hahn. “This is an approach that we would like to see move forward into clinical trials and ultimately into a commercially available test.”last_img read more