Group finds circadian clock common to almost all life forms

first_img © 2012 Phys.Org The peroxiredoxin active site is highly conserved in all domains of life. Image: Nature (2012) doi:10.1038/nature11088 Up till now, researchers have not been able to find any kind of common biorhythmic clock among the Earth’s varied organisms, each class seemed to have its own. They did find though that one common feature of most was a feedback loop, which is where genes are transcribed before being translated into proteins which then build up until they reach a tipping point. Once that happens, transcription is turned off and the enzyme goes dormant. This cycle, for most organisms occurs on a twenty four hour basis, and is responsible for such things as the feelings of sleepiness or hunger in people that occur at roughly the same time each day.But now, this new research suggests that the true clock controlling behavior in virtually every imaginable plant, animal, fungus, etc. has its roots in an enzyme whose purpose is to help clean up residue left over from the ravages of antioxidants.Peroxiredoxins, which exist in virtually all life forms, are enzymes that cycle between two states depending on whether they have reacted recently with hydrogen peroxide, or not. The researchers found that this cycle occurs on a roughly twenty four hour cycle in all of the organisms they’ve tested to date. What’s more, the cycle continued even in the absence of light, proving that it’s not part of a feedback loop. Unfortunately, the team has not yet been able to show how or if the enzyme controls other clock mechanisms that are a part of feedback loops.The team suggests that peroxiredoxins developed their cyclical behavior just after organisms began to develop some two and half billion years ago that were able to handle the increased amounts of oxygen that had begun to appear in the atmosphere in a time period known as the Great Oxidation Event; the time when bacteria developed photosynthesis and began pumping out oxygen. Those organisms that managed to survive had to develop a means of dealing with the damage caused by antioxidants, and thus was born the role of peroxiredoxins. And because oxygen levels rose and fell on a regular daily schedule, the enzymes developed a clock over time to help predict when to go to work, and when to remain dormant, thus paving the way for the first circadian clock. Citation: Group finds circadian clock common to almost all life forms (2012, May 17) retrieved 18 August 2019 from More information: Peroxiredoxins are conserved markers of circadian rhythms, Nature (2012) doi:10.1038/nature11088AbstractCellular life emerged ~3.7 billion years ago. With scant exception, terrestrial organisms have evolved under predictable daily cycles owing to the Earth’s rotation. The advantage conferred on organisms that anticipate such environmental cycles has driven the evolution of endogenous circadian rhythms that tune internal physiology to external conditions. The molecular phylogeny of mechanisms driving these rhythms has been difficult to dissect because identified clock genes and proteins are not conserved across the domains of life: Bacteria, Archaea and Eukaryota. Here we show that oxidation–reduction cycles of peroxiredoxin proteins constitute a universal marker for circadian rhythms in all domains of life, by characterizing their oscillations in a variety of model organisms. Furthermore, we explore the interconnectivity between these metabolic cycles and transcription–translation feedback loops of the clockwork in each system. Our results suggest an intimate co-evolution of cellular timekeeping with redox homeostatic mechanisms after the Great Oxidation Event ~2.5 billion years ago.Press release Journal information: Naturelast_img read more